It is often suggested that during development the brain barriers are immature. This argument stems from teleological interpretations and experimental observations of the high protein concentrations in fetal cerebrospinal fluid (CSF) and decreases in apparent permeability of passive markers during development. We argue that the developmental blood–CSF barrier restricts the passage of lipid‐insoluble molecules by the same mechanism as in the adult (tight junctions) rendering the paracellular pathway an unlikely route of entry. Instead, we suggest that both protein and passive (...) markers are transferred across the epithelium through a transcellular route. We propose that changes in volume of distribution can largely explain the decrease in apparent permeability for passive markers and that developmentally regulated cellular transfer explains changes in CSF protein concentrations. The blood–CSF tight junctions are functionally mature from very early in development, and it appears that transfer from blood into embryonic brain occurs predominately via CSF rather than the vasculature. BioEssays 30:237–248, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The Mental Capacity Act 2005 gives statutory force to the common law principle that all adults are assumed to have capacity to make decisions unless proven otherwise. In accord with best practice, this principle places the evidential burden on researchers rather than participants and requires researchers to take account of short-term and transient understandings common among some research populations. The aim of this paper is to explore some of the implications of the MCA 2005 for researchers working with 'vulnerable' populations (...) in health and social care settings. The Cyclical Consent Model is described and offered as a process by which researchers might develop good practice when engaged in research involving vulnerable people. (shrink)

“…we are left with a choice between saying that Mark was simply incompetent, or that the ending, though strange, is right if rightly (finely) interpreted. We have to explain why a book that begins so triumphantly and makes promises of a certain kind ends in silence and dismay, without fulfilling the promises.”1 (Frank Kermode.).

Dienes & Perner make three mistakes in their account of the “natural language meaning” of implicit-explicit knowledge: They fail to take the multiplicity of use of a concept seriously enough, they arbitrarily separate use of a concept and its conceptual structure, and they tend to tailor their analysis for use by the Representational Theory of Knowledge.

Alexandre Grothendieck foi um dos maiores matemáticos do século 20 e um dos mais atípicos. Nascido na Alemanha a um pai anarquista de origem russa, sua infância foi marcada pela militância política dos seus pais, assim passando por revoluções, guerras e sobrevivência. Descoberto por sua precocidade matemática por Henri Cartan, Grothendieck fez seu doutorado sob orientação de Laurent Schwartz e Jean Dieudonné. As principais contribuições dele são na área da topologia e na geometria algébrica, assim como na teoria das categorias. (...) No final dos anos de 1960, ele se dedicou à militância política e ecológica, organizando a revista Survivre durante três anos. Em 1986, publicou um manuscrito autobiográfico de 1000 páginas, Récoltes et semailles, em que ele descreve sua experiência e sua prática da matemática, assim suas contribuições à comunidade matemática francesa. Pouco comentado na filosofia, as implicações dos seus descobrimentos fora mais recentemente discutidas por Alain Badiou na sua "fenômeno-lógica", em Logiques des mondes e Arkady Plonitsky, Mathgematics, Science and postclassical Theory, pesquisa trata da semelhança entre os aspectos formais da filosofia de Gilles Deleuze e da topologia de Grothendieck. (shrink)